This report discusses entrepreneurship in the EUROACE region i.e. the three European regions of Alentejo, Centro and Extremadura, in the period June 2014 to February 2015. 7.6% of the population between 18 and 64 years old has been involved in entrepreneurial activities in the EUROACE region. The Portuguese region of Centro obtained the highest rate of entrepreneurial activity (TEA) with 7.8% of entrepreneurs, whereas Alentejo has 7.1% and the Spanish region of Extremadura 7.4%.