This report examines the COVID-19 impact on entrepreneurship in Saskatchewan for 2021 using data from the Global Entrepreneurship Monitor (GEM). The report presents findings from COVID-19 specific questions which were included in a GEM adult population survey conducted in 2021 across the four Western Provinces. The report is offered in conjunction with the like reports of the Gem Study of COVID-19 Impacts on Entrepreneurship in Alberta 2021 and the GEM Provincial Report for Manitoba 2021.The report then explores topics specific to Woman and Youth entrepreneurs in Saskatchewan in 2021. The responses and analysis specific to Saskatchewan are drawn from the GEM reports Women’s Entrepreneurship in Western Canada: Results from the GEM Canada 2021 Survey and Youth Entrepreneurship in Western Canada.